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\nThe researchers are now investigating whether a similar gut microbiome and brain activity pathway exists in humans, and whether it also contributes to age-related cognitive decline. Importantly, vagus nerve stimulation is approved by the Food and Drug Administration as a treatment for depression or epilepsy and to aid stroke recovery. The researchers are also interested in developing ways to non-invasively monitor, and perhaps even control, the activity of peripheral neurons to affect memory formation and cognition.

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When they treated old mice with a molecule that activates the vagus nerve, however, the cognitive performance of the animals was indistinguishable from that of young animals.

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